Cardiovascular disorders in narcolepsy: Review of associations and determinants

نویسندگان

چکیده

Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined by clinical symptoms, neurophysiological findings, and low hypocretin levels. Besides role in sleep, hypocretins are also involved regulation heart rate blood pressure. This literature review examines data on the autonomic effects deficiency evidence about how narcolepsy associated with multiple cardiovascular risk factors comorbidities, including disease. An important impact NT1 lack nocturnal pressure dipping, which has been mortality general population. Hypertension prevalent NT1. Furthermore, disrupted nighttime sleep excessive daytime sleepiness, characteristic narcolepsy, may increase risk. Patients often present other comorbidities (eg, obesity, diabetes, depression, disorders) that contribute to increased Management multimorbidity patients should include regular assessment health (including ambulatory monitoring), mitigation cessation smoking lifestyle changes, hygiene, pharmacotherapy), prescription regimen medications balances symptomatic benefits safety.

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ژورنال

عنوان ژورنال: Sleep Medicine Reviews

سال: 2021

ISSN: ['1087-0792', '1532-2955']

DOI: https://doi.org/10.1016/j.smrv.2021.101440